Ectodomain Shedding by ADAM17 Increases the Release of Soluble CD40 from Human Endothelial Cells under Pro-Inflammatory Conditions

Ectodomain Shedding by ADAM17 Increases the Release of Soluble CD40 from Human Endothelial Cells under Pro-Inflammatory Conditions

Background: Homozygosity for the C allele of the −1T>C single nucleotide polymorphism (SNP) of the <i>CD40</i> gene (rs1883832) is associated with susceptibility to coronary heart disease (CHD), enhanced CD40 expression, and shedding. The disintegrin metalloprotease ADAM17 can cleave...

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Bibliographic Details
Main Authors: Anton Klersy, Sören Meyer, Florian Leuschner, Thorsten Kessler, Markus Hecker, Andreas H. Wagner
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cells
Subjects:
single nucleotide polymorphism
soluble CD40
biomarker
ADAM17
endothelial cells
Online Access:https://www.mdpi.com/2073-4409/12/15/1926

Internet

https://www.mdpi.com/2073-4409/12/15/1926

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