Single amino acid substitutions in hydrophobic cores at a head-coiled coil junction region of cohesin facilitate its release of DNA during anaphase

Single amino acid substitutions in hydrophobic cores at a head-coiled coil junction region of cohesin facilitate its release of DNA during anaphase

Cohesin holds sister chromatids together and is cleaved by separase/Cut1 to release DNA during the transition from mitotic metaphase to anaphase. The cohesin complex consists of heterodimeric structural maintenance of chromosomes (SMC) subunits (Psm1 and Psm3), which possess a head and a hinge, sepa...

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Bibliographic Details
Main Authors: Xingya Xu, Ryuta Kanai, Li Wang, Mitsuhiro Yanagida
Format: Article
Language:English
Published: The Royal Society 2022-04-01
Series:Open Biology
Subjects:
saturation mutagenesis
suppressor screen
cohesin
hydrophobic core
coiled coils
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.210275

Internet

https://royalsocietypublishing.org/doi/10.1098/rsob.210275

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