S-allylmercapto-N-acetylcysteine ameliorates pulmonary fibrosis in mice via Nrf2 pathway activation and NF-κB, TGF-β1/Smad2/3 pathway suppression

S-allylmercapto-N-acetylcysteine ameliorates pulmonary fibrosis in mice via Nrf2 pathway activation and NF-κB, TGF-β1/Smad2/3 pathway suppression

Pulmonary fibrosis (PF) is a chronic lung disease characterised by alveolar inflammatory injury, alveolar septal thickening, and eventually fibrosis. Patients with severe Coronavirus Disease 2019 (COVID-19) may have left a certain degree of pulmonary fibrosis. PF is commonly caused by oxidative imba...

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Bibliographic Details
Main Authors: Qinxiu Zhang, Wenhui Ye, Ying Liu, Decao Niu, Xin Zhao, Genjv Li, Ying Qu, Zhongxi Zhao
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
COVID-19
Pulmonary fibrosis
ASSNAC
Oxidative stress
Inflammation
TGF-β1/Smad2/3 pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222201407X

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http://www.sciencedirect.com/science/article/pii/S075333222201407X

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