A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene

A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene

Previously we showed the generation of a protein trap library made with the gene-break transposon (GBT) in zebrafish (Danio rerio) that could be used to facilitate novel functional genome annotation towards understanding molecular underpinnings of human diseases (Ichino et al, 2020). Here, we report...

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Bibliographic Details
Main Authors: Yonghe Ding, Di Lang, Jianhua Yan, Haisong Bu, Hongsong Li, Kunli Jiao, Jingchun Yang, Haibo Ni, Stefano Morotti, Tai Le, Karl J Clark, Jenna Port, Stephen C Ekker, Hung Cao, Yuji Zhang, Jun Wang, Eleonora Grandi, Zhiqiang Li, Yongyong Shi, Yigang Li, Alexey V Glukhov, Xiaolei Xu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-10-01
Series:eLife
Subjects:
sick sinus syndrome
sinus arrest
Dnajb6
electrocardiogram
genetic diseases
zebrafish
Online Access:https://elifesciences.org/articles/77327

Internet

https://elifesciences.org/articles/77327

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