Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2

Abstract Hydroxycarboxylic acid receptor 2 (HCAR2) belongs to the family of class A G protein-coupled receptors with key roles in regulating lipolysis and free fatty acid formation in humans. It is deeply involved in many pathophysiological processes and serves as an attractive target for the treatm...

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Bibliographic Details
Main Authors: Xin Pan, Fang Ye, Peiruo Ning, Zhiyi Zhang, Xinyu Li, Binghao Zhang, Qian Wang, Geng Chen, Wei Gao, Chen Qiu, Zhangsong Wu, Jiancheng Li, Lizhe Zhu, Jiang Xia, Kaizheng Gong, Yang Du
Format: Article
Language:English
Published: Nature Publishing Group 2023-11-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-023-00610-7