Two New Dihydrosphingosine Analogs Against Mycobacterium tuberculosis Affect gltA1, lprQ, and rpsO Expression

Two New Dihydrosphingosine Analogs Against Mycobacterium tuberculosis Affect gltA1, lprQ, and rpsO Expression

The emergence of multidrug-resistant (MDR) Mycobacterium tuberculosis strains threaten the control of tuberculosis. New antitubercular dihydrosphingosine analogs, named UCIs, have been evaluated in preclinical studies but their cellular and molecular mechanisms of action against M. tuberculosis are...

Full description

Bibliographic Details
Main Authors: Katia Peñuelas-Urquides, Mario Bermúdez de León, Beatriz Silva-Ramírez, Fabiola Castorena-Torres, Gloria María Molina-Salinas, Jorge Castro-Garza, Pola Becerril-Montes, Esther del Olmo, Arturo San Feliciano, Laura Adiene González-Escalante, Licet Villarreal-Treviño, Salvador Said-Fernández
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Microbiology
Subjects:
Mycobacterium tuberculosis
multidrug-resistance
gene expression
antitubercular drugs
dihydrosphingosine analogs
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.742867/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.742867/full

Similar Items