A Plumieridine-Rich Fraction From Allamanda polyantha Inhibits Chitinolytic Activity and Exhibits Antifungal Properties Against Cryptococcus neoformans

A Plumieridine-Rich Fraction From Allamanda polyantha Inhibits Chitinolytic Activity and Exhibits Antifungal Properties Against Cryptococcus neoformans

Cryptococcosis is a fungal infection caused mainly by the pathogenic yeasts Cryptococcus neoformans and Cryptococcus gattii. The infection initiates with the inhalation of propagules that are then deposited in the lungs. If not properly treated, cryptococci cells can disseminate and reach the centra...

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Bibliographic Details
Main Authors: Eden Silva e Souza, Vanessa de Abreu Barcellos, Nicolau Sbaraini, Júlia Catarina Vieira Reuwsaat, Rafael de Oliveira Schneider, Adriana Corrêa da Silva, Ane Wichine Acosta Garcia, Gilsane Lino von Poser, Euzébio Guimarães Barbosa, João Paulo Matos Santos Lima, Marilene Henning Vainstein
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Microbiology
Subjects:
Cryptococcus neoformans
target prediction
chitinase
plumieridine
antifungal activity
drug discovery
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.02058/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.02058/full

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