De Novo Noninversion Variants Implicated in Sporadic Hemophilia A: A Variant Origin and Timing Study

De Novo Noninversion Variants Implicated in Sporadic Hemophilia A: A Variant Origin and Timing Study

Sporadic hemophilia A (HA) enables the persistence of HA in the population. <i>F8</i> gene inversion originates mainly in male germ cells during meiosis. To date, no studies have shown the origin and timing of HA sporadic noninversion variants (NIVs); herein, we assume that HA-sporadic N...

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Bibliographic Details
Main Authors: Ming Chen, Ming-Ching Shen, Shun-Ping Chang, Gwo-Chin Ma, Dong-Jay Lee, Adeline Yan
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
de novo variant
noninversion variant
sporadic hemophilia A
hemophilia A
mosaic variant
germline mosaicism
Online Access:https://www.mdpi.com/1422-0067/25/3/1763

Internet

https://www.mdpi.com/1422-0067/25/3/1763

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