SPAK-p38 MAPK signal pathway modulates claudin-18 and barrier function of alveolar epithelium after hyperoxic exposure

SPAK-p38 MAPK signal pathway modulates claudin-18 and barrier function of alveolar epithelium after hyperoxic exposure

Abstract Background Hyperoxia downregulates the tight junction (TJ) proteins of the alveolar epithelium and leads to barrier dysfunction. Previous study has showed that STE20/SPS1-related proline/alanine-rich kinase (SPAK) interferes with the intestinal barrier function in mice. The aim of the prese...

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Bibliographic Details
Main Authors: Chih-Hao Shen, Jr-Yu Lin, Cheng-Yo Lu, Sung-Sen Yang, Chung-Kan Peng, Kun-Lun Huang
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Pulmonary Medicine
Subjects:
STE20/SPS1-related proline/alanine-rich kinase
Hyperoxia
Alveolar epithelium
Claudin-18
p38 MAPK
Online Access:https://doi.org/10.1186/s12890-021-01408-7

Internet

https://doi.org/10.1186/s12890-021-01408-7

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