G6PD maintains the VSMC synthetic phenotype and accelerates vascular neointimal hyperplasia by inhibiting the VDAC1–Bax-mediated mitochondrial apoptosis pathway

G6PD maintains the VSMC synthetic phenotype and accelerates vascular neointimal hyperplasia by inhibiting the VDAC1–Bax-mediated mitochondrial apoptosis pathway

Abstract Background Glucose-6-phosphate dehydrogenase (G6PD) plays an important role in vascular smooth muscle cell (VSMC) phenotypic switching, which is an early pathogenic event in various vascular remodeling diseases (VRDs). However, the underlying mechanism is not fully understood. Methods An IP...

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Bibliographic Details
Main Authors: Ting Zhang, Rui-Jie Cao, Jiang-Ling Niu, Zhi-Huan Chen, Shi-Qing Mu, Tong Cao, Jie-Xin Pang, Li-Hua Dong
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Cellular & Molecular Biology Letters
Subjects:
Vascular smooth muscle cells
Apoptosis
G6PD
VDAC1
Bax
Online Access:https://doi.org/10.1186/s11658-024-00566-w

Internet

https://doi.org/10.1186/s11658-024-00566-w

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