Altered Ca<sup>2+</sup> Homeostasis in Red Blood Cells of Polycythemia Vera Patients Following Disturbed Organelle Sorting during Terminal Erythropoiesis

Altered Ca<sup>2+</sup> Homeostasis in Red Blood Cells of Polycythemia Vera Patients Following Disturbed Organelle Sorting during Terminal Erythropoiesis

Over 95% of Polycythemia Vera (PV) patients carry the V617F mutation in the tyrosine kinase Janus kinase 2 (JAK2), resulting in uncontrolled erythroid proliferation and a high risk of thrombosis. Using mass spectrometry, we analyzed the RBC membrane proteome and showed elevated levels of multiple Ca...

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Detaylı Bibliyografya
Asıl Yazarlar: Ralfs Buks, Tracy Dagher, Maria Giustina Rotordam, David Monedero Alonso, Sylvie Cochet, Emilie-Fleur Gautier, Philippe Chafey, Bruno Cassinat, Jean-Jacques Kiladjian, Nadine Becker, Isabelle Plo, Stéphane Egée, Wassim El Nemer
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: MDPI AG 2021-12-01
Seri Bilgileri:Cells
Konular:
polycythemia vera
JAK2V617F
red blood cells
Ca<sup>2+</sup>
organelle sorting
enucleation
Online Erişim:https://www.mdpi.com/2073-4409/11/1/49

Internet

https://www.mdpi.com/2073-4409/11/1/49

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