The CEL-HYB1 Hybrid Allele Promotes Digestive Enzyme Misfolding and Pancreatitis in MiceSummary

The CEL-HYB1 Hybrid Allele Promotes Digestive Enzyme Misfolding and Pancreatitis in MiceSummary

Background & Aims: A hybrid allele that originated from homologous recombination between CEL and its pseudogene (CELP), CEL-HYB1 increases the risk of chronic pancreatitis (CP). Although suggested to cause digestive enzyme misfolding, definitive in vivo evidence for this postulate has been l...

Full description

Bibliographic Details
Main Authors: Xiao-Tong Mao, MD, Wen-Bin Zou, MD, Yu Cao, MD, Yuan-Chen Wang, BM, Shun-Jiang Deng, BM, David N. Cooper, PhD, Claude Férec, MD, PhD, Zhao-Shen Li, MD, Jian-Min Chen, MD, PhD, Zhuan Liao, MD
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Carboxyl Ester Lipase
Chronic Pancreatitis
Genetic Variants
Protein Misfolding
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X22000650

Internet

http://www.sciencedirect.com/science/article/pii/S2352345X22000650

Similar Items