The CEL-HYB1 Hybrid Allele Promotes Digestive Enzyme Misfolding and Pancreatitis in MiceSummary

The CEL-HYB1 Hybrid Allele Promotes Digestive Enzyme Misfolding and Pancreatitis in MiceSummary

Background & Aims: A hybrid allele that originated from homologous recombination between CEL and its pseudogene (CELP), CEL-HYB1 increases the risk of chronic pancreatitis (CP). Although suggested to cause digestive enzyme misfolding, definitive in vivo evidence for this postulate has been l...

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Bibliographic Details
Main Authors: Xiao-Tong Mao, MD, Wen-Bin Zou, MD, Yu Cao, MD, Yuan-Chen Wang, BM, Shun-Jiang Deng, BM, David N. Cooper, PhD, Claude Férec, MD, PhD, Zhao-Shen Li, MD, Jian-Min Chen, MD, PhD, Zhuan Liao, MD
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Carboxyl Ester Lipase
Chronic Pancreatitis
Genetic Variants
Protein Misfolding
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X22000650

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