Inhibition of Allograft Inflammatory Factor-1 in Dendritic Cells Restrains CD4+ T Cell Effector Responses and Induces CD25+Foxp3+ T Regulatory Subsets

Inhibition of Allograft Inflammatory Factor-1 in Dendritic Cells Restrains CD4+ T Cell Effector Responses and Induces CD25+Foxp3+ T Regulatory Subsets

Allograft inflammatory factor-1 (AIF1) is a cytoplasmic scaffold protein shown to influence immune responses in macrophages and microglial cells. The protein contains Ca2+ binding EF-hand and PDZ interaction domains important for mediating intracellular signaling complexes. This study now reports th...

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Bibliographic Details
Main Authors: Diana M. Elizondo, Temesgen E. Andargie, Dazhi Yang, Apollo D. Kacsinta, Michael W. Lipscomb
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
dendritic cells
T regulatory cells
tolerogenic
polarization
suppression
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01502/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01502/full

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