Cellular Mechanisms Underlying B Cell Abnormalities in Patients With Gain-of-Function Mutations in the PIK3CD Gene

Cellular Mechanisms Underlying B Cell Abnormalities in Patients With Gain-of-Function Mutations in the PIK3CD Gene

BackgroundActivated phosphoinositide 3 kinase (PI3K) -delta syndrome (APDS) is an inborn error of immunity with variable clinical phenotype of immunodeficiency and immune dysregulation and caused by gain-of-function mutations in PIK3CD. The hallmark of immune phenotype is increased proportions of tr...

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Bibliographic Details
Main Authors: Wenjie Wang, Qing Min, Nannan Lai, Krisztian Csomos, Ying Wang, Luyao Liu, Xin Meng, Jinqiao Sun, Jia Hou, Wenjing Ying, Qinhua Zhou, Bijun Sun, Xiaoying Hui, Boglarka Ujhazi, Sumai Gordon, David Buchbinder, Catharina Schuetz, Manish Butte, Jolan E. Walter, Xiaochuan Wang, Ji-Yang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
activated PI3Kδ syndrome (APDS)
B cell survival and activation
CD27-IgD- double-negative B cells
Ig gene class switch recombination
plasma cell differentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.890073/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.890073/full

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