Epigallocatechin-3-gallate pretreatment alleviates doxorubicin-induced ferroptosis and cardiotoxicity by upregulating AMPKα2 and activating adaptive autophagy

Epigallocatechin-3-gallate pretreatment alleviates doxorubicin-induced ferroptosis and cardiotoxicity by upregulating AMPKα2 and activating adaptive autophagy

Reports indicate that the mechanism of doxorubicin (Dox)-induced cardiotoxicity is very complex, involving multiple regulatory cell death forms. Furthermore, the clinical intervention effect is not ideal. Iron dependence, abnormal lipid metabolism, and excess reactive oxygen species generation, thre...

Full description

Bibliographic Details
Main Authors: Huan He, Liang Wang, Yang Qiao, Bin Yang, Dong Yin, Ming He
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Redox Biology
Subjects:
AMP-Activated protein kinase α2
Autophagy
Cardiotoxicity
Doxorubicin
Epigallocatechin-3-gallate
Ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721003451

Internet

http://www.sciencedirect.com/science/article/pii/S2213231721003451

Similar Items