Kirenol alleviates diabetic nephropathy via regulating TGF-β/Smads and the NF-κB signal pathway

Kirenol alleviates diabetic nephropathy via regulating TGF-β/Smads and the NF-κB signal pathway

Context Kirenol possesses anti-inflammatory, antifibrotic and anti-arthritic effects. However, its reno-protective effects against diabetic nephropathy (DN) have not been evaluated.Objective This study explores the reno-protective effects of kirenol against DN and clarifies the potential mechanisms....

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Bibliographic Details
Main Authors: Jialin Li, Jiawen Zhang, Meng Yang, Xiaocui Huang, Meng Zhang, Xiansong Fang, Suzhen Wu
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Pharmaceutical Biology
Subjects:
TNF-α
IL-6
mesangial cells
fibronectin
collagen IV
Online Access:https://www.tandfonline.com/doi/10.1080/13880209.2022.2112239

Internet

https://www.tandfonline.com/doi/10.1080/13880209.2022.2112239

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