Inhibition of lysosomal Ca2+ signalling disrupts dendritic spine structure and impairs wound healing in neurons

A growing body of evidence suggests that lysosomes, which have traditionally been regarded as degradative organelles, can function as Ca2+ stores, regulated by the second messenger nicotinic acid adenine dinucleotide phosphate (NAADP). We previously demonstrated that in hippocampal pyramidal neurons...

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Detalhes bibliográficos
Main Authors: Zahid Padamsey, Lindsay McGuinness, Nigel J. Emptage
Formato: Artigo
Idioma:English
Publicado em: Taylor & Francis Group 2017-11-01
Colecção:Communicative & Integrative Biology
Assuntos:
Acesso em linha:http://dx.doi.org/10.1080/19420889.2017.1344802