Immunogenicity and protective efficacy of a rhesus adenoviral vaccine targeting conserved COVID-19 replication transcription complex

Immunogenicity and protective efficacy of a rhesus adenoviral vaccine targeting conserved COVID-19 replication transcription complex

Abstract The COVID-19 pandemic marks the third coronavirus pandemic this century (SARS-CoV-1, MERS, SARS-CoV-2), emphasizing the need to identify and evaluate conserved immunogens for a pan-sarbecovirus vaccine. Here we investigate the potential utility of a T-cell vaccine strategy targeting conserv...

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Bibliographic Details
Main Authors: Gabriel Dagotto, John D. Ventura, David R. Martinez, Tochi Anioke, Benjamin S. Chung, Mazuba Siamatu, Julia Barrett, Jessica Miller, Alexandra Schäfer, Jingyou Yu, Lisa H. Tostanoski, Kshitij Wagh, Ralph S. Baric, Bette Korber, Dan H. Barouch
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-022-00553-2

Internet

https://doi.org/10.1038/s41541-022-00553-2

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