Temozolomide Induces the Acquisition of Invasive Phenotype by O6-Methylguanine-DNA Methyltransferase (MGMT)<sup>+</sup> Glioblastoma Cells in a Snail-1/Cx43-Dependent Manner

Temozolomide Induces the Acquisition of Invasive Phenotype by O6-Methylguanine-DNA Methyltransferase (MGMT)<sup>+</sup> Glioblastoma Cells in a Snail-1/Cx43-Dependent Manner

Glioblastoma multiforme (GBM) recurrences after temozolomide (TMZ) treatment result from the expansion of drug-resistant and potentially invasive GBM cells. This process is facilitated by O6-Methylguanine-DNA Methyltransferase (MGMT), which counteracts alkylating TMZ activity. We traced the expansio...

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Bibliographic Details
Main Authors: Paweł Kochanowski, Jessica Catapano, Maciej Pudełek, Tomasz Wróbel, Zbigniew Madeja, Damian Ryszawy, Jarosław Czyż
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
Cx43
glioblastoma multiforme
drug-resistance
MGMT
Snail-1
microevolution
Online Access:https://www.mdpi.com/1422-0067/22/8/4150

Internet

https://www.mdpi.com/1422-0067/22/8/4150

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