Intratumoral delivered novel circular mRNA encoding cytokines for immune modulation and cancer therapy

Intratumoral delivered novel circular mRNA encoding cytokines for immune modulation and cancer therapy

The success of the two mRNA vaccines developed by Moderna and BioNTech during the COVID-19 pandemic increased research interest into the application of mRNA technologies. Compared with the canonical linear mRNA used in these vaccines, circular mRNA has been found to mediate more potent and durable p...

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Bibliographic Details
Main Authors: Jiali Yang, Jiafeng Zhu, Jiaojiao Sun, Yiyun Chen, Yaran Du, Yiling Tan, Linpeng Wu, Mengting Zhai, Lixiang Wei, Na Li, Ke Huang, Qiangbo Hou, Zhenbo Tong, Andreas Bechthold, Hao Tian, Zhenhua Sun, Chijian Zuo
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
circular mRNA
IRES
cytokines
intratumoral injection
cancer therapy
tumor microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253122002530

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http://www.sciencedirect.com/science/article/pii/S2162253122002530

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