Mesenchymal stem/stromal cells primed by inflammatory cytokines alleviate psoriasis-like inflammation via the TSG-6-neutrophil axis

Mesenchymal stem/stromal cells primed by inflammatory cytokines alleviate psoriasis-like inflammation via the TSG-6-neutrophil axis

Abstract Psoriasis is currently an incurable skin disorder mainly driven by a chronic inflammatory response. We found that subcutaneous application of umbilical cord- derived mesenchymal stem/stromal cells (MSCs) primed by IFN-γ and TNF-α, referred to as MSCs-IT, exhibited remarkable therapeutic eff...

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Bibliographic Details
Main Authors: Yayun Ding, Pixia Gong, Junjie Jiang, Chao Feng, Yanan Li, Xiao Su, Xiaojing Bai, Chenchang Xu, Chunxiao Liu, Jianxin Yang, Jiankai Fang, Xiaocao Ji, Yongjing Chen, Peishan Li, Lingchuan Guo, Changshun Shao, Yufang Shi
Format: Article
Language:English
Published: Nature Publishing Group 2022-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05445-w

Internet

https://doi.org/10.1038/s41419-022-05445-w

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