The ATM Ser49Cys Variant Effects ATM Function as a Regulator of Oncogene-Induced Senescence

The ATM Ser49Cys Variant Effects ATM Function as a Regulator of Oncogene-Induced Senescence

An apical component of the cell cycle checkpoint and DNA damage repair response is the ataxia-telangiectasia mutated (ATM) Ser/Thr protein kinase. A variant of ATM, Ser49Cys (rs1800054; minor allele frequency = 0.011), has been associated with an elevated risk of melanoma development; however, the f...

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Bibliographic Details
Main Authors: Caroline Atkinson, Aideen M. McInerney-Leo, Martina Proctor, Catherine Lanagan, Alexander J. Stevenson, Farhad Dehkhoda, Mary Caole, Ellie Maas, Stephen Ainger, Antonia L. Pritchard, Peter A. Johansson, Paul Leo, Nicholas K. Hayward, Richard A. Sturm, Emma L. Duncan, Brian Gabrielli
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
ATM
p53
ionising radiation
DNA damage
senescence
Online Access:https://www.mdpi.com/1422-0067/25/3/1664

Internet

https://www.mdpi.com/1422-0067/25/3/1664

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