Annual stability of the plasma Aß40/42 ratio and associated factors

Abstract Objective The plasma Aß40/42 ratio is a biomarker of brain amyloidosis. However, the threshold difference between amyloid positivity and negativity is only 10–20% and fluctuates with circadian rhythms, aging, and APOE‐ε4 during the decades of evolution of Alzheimer's disease. Methods P...

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Bibliographic Details
Main Authors: Takumi Nakamura, Takeshi Kawarabayashi, Naoko Nakahata, Ken Itoh, Kazushige Ihara, Shigeyuki Nakaji, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji
Format: Article
Language:English
Published: Wiley 2023-06-01
Series:Annals of Clinical and Translational Neurology
Online Access:https://doi.org/10.1002/acn3.51770