Automating data analysis for hydrogen/deuterium exchange mass spectrometry using data-independent acquisition methodology

Automating data analysis for hydrogen/deuterium exchange mass spectrometry using data-independent acquisition methodology

Abstract We present a hydrogen/deuterium exchange workflow coupled to tandem mass spectrometry (HX-MS2) that supports the acquisition of peptide fragment ions alongside their peptide precursors. The approach enables true auto-curation of HX data by mining a rich set of deuterated fragments, generate...

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Bibliographic Details
Main Authors: Frantisek Filandr, Vladimir Sarpe, Shaunak Raval, D. Alex Crowder, Morgan F. Khan, Pauline Douglas, Stephen Coales, Rosa Viner, Aleem Syed, John A. Tainer, Susan P. Lees-Miller, David C. Schriemer
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46610-3

Internet

https://doi.org/10.1038/s41467-024-46610-3

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