Phytochemicals from Corchorus olitorius methanolic extract induce apoptotic cell death via activation of caspase-3, anti-Bcl-2 activity, and DNA degradation in breast and lung cancer cell lines

Phytochemicals from Corchorus olitorius methanolic extract induce apoptotic cell death via activation of caspase-3, anti-Bcl-2 activity, and DNA degradation in breast and lung cancer cell lines

Objectives: The main objective of the present research is to provide GC–MS and LC-MS phytochemcial profiling of Corchorus olitorius along with Flow cytometry based mechanistic investigation of cytotoxic activity of its extracts against breast and lung cancer cell lines. Methods: The Soxhlet extracti...

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Bibliographic Details
Main Authors: Ali Mohamed Alshabi, Saad Ahmed Alkahtani, Ibrahim Ahmed Shaikh, Mohamed A.A. Orabi, Basel A. Abdel-Wahab, Ismail A. Walbi, Mohammed S. Habeeb, Masood Medleri Khateeb, Joy H. Hoskeri, Arun K. Shettar, Syed Mohammed Basheeruddin Asdaq
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Journal of King Saud University: Science
Subjects:
Corchorus olitorius
Breast cancer
Lung cancer
Apoptosis
Bcl-2
Caspase-3
Online Access:http://www.sciencedirect.com/science/article/pii/S1018364722004190

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http://www.sciencedirect.com/science/article/pii/S1018364722004190

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