Nuclear FGFR2 Interacts with the MLL-AF4 Oncogenic Chimera and Positively Regulates <i>HOXA9</i> Gene Expression in t(4;11) Leukemia Cells

Nuclear FGFR2 Interacts with the MLL-AF4 Oncogenic Chimera and Positively Regulates <i>HOXA9</i> Gene Expression in t(4;11) Leukemia Cells

The chromosomal translocation t(4;11) marks an infant acute lymphoblastic leukemia associated with dismal prognosis. This rearrangement leads to the synthesis of the MLL-AF4 chimera, which exerts its oncogenic activity by upregulating transcription of genes involved in hematopoietic differentiation....

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Bibliographic Details
Main Authors: Tiziana Fioretti, Armando Cevenini, Mariateresa Zanobio, Maddalena Raia, Daniela Sarnataro, Fabio Cattaneo, Rosario Ammendola, Gabriella Esposito
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
AF4
cell culture
FGFR2
<i>HOXA9</i>
MLL-AF4
nucleus
Online Access:https://www.mdpi.com/1422-0067/22/9/4623

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https://www.mdpi.com/1422-0067/22/9/4623

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