Synthesis of Novel Benzimidazole-Based Thiazole Derivatives as Multipotent Inhibitors of α-Amylase and α-Glucosidase: In Vitro Evaluation along with Molecular Docking Study

Synthesis of Novel Benzimidazole-Based Thiazole Derivatives as Multipotent Inhibitors of α-Amylase and α-Glucosidase: In Vitro Evaluation along with Molecular Docking Study

In this study, hybrid analogs of benzimidazole containing a thiazole moiety (<b>1</b>–<b>17</b>) were afforded and then tested for their ability to inhibit α-amylase and α-glucosidase when compared to acarbose as a standard drug. The recently available analogs showed a wide v...

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Bibliographic Details
Main Authors: Rafaqat Hussain, Shahid Iqbal, Mazloom Shah, Wajid Rehman, Shoaib Khan, Liaqat Rasheed, Fazal Rahim, Ayed A. Dera, Sana Kehili, Eslam B. Elkaeed, Nasser S. Awwad, Majed A. Bajaber, Mohammed Issa Alahmdi, Hamad Alrbyawi, Hashem O. Alsaab
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
synthesis
benzimidazole bearing thiazole analogs
α-glucosidase
α-amylase
molecular docking
Online Access:https://www.mdpi.com/1420-3049/27/19/6457

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https://www.mdpi.com/1420-3049/27/19/6457

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