The STRIPAK complex components FAM40A and FAM40B regulate endothelial cell contractility via ROCKs

The STRIPAK complex components FAM40A and FAM40B regulate endothelial cell contractility via ROCKs

Abstract Background Endothelial cells provide a barrier between blood and tissues, which is regulated to allow molecules and cells in out of tissues. Patients with cerebral cavernous malformations (CCM) have dilated leaky blood vessels, especially in the central nervous system. A subset of these pat...

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Bibliographic Details
Main Authors: Narendra Suryavanshi, Joanna Furmston, Anne J. Ridley
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Cell Biology
Subjects:
Cerebral cavernous malformations
Endothelial cells
Actin cytoskeleton
Adherens junctions
Rho/ROCK
STRIPAK complex
Online Access:http://link.springer.com/article/10.1186/s12860-018-0175-y

Internet

http://link.springer.com/article/10.1186/s12860-018-0175-y

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