Dimethyl malonate preserves renal and mitochondrial functions following ischemia-reperfusion via inhibition of succinate dehydrogenase

Dimethyl malonate preserves renal and mitochondrial functions following ischemia-reperfusion via inhibition of succinate dehydrogenase

Background: Acute kidney injury (AKI), often experienced at the intensive care units, is associated with high morbidity/mortality where ischemia-reperfusion injury is a main causative factor. Succinate accumulation during ischemia contributes to the excessive generation of reactive oxygen species at...

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Bibliographic Details
Main Authors: Mattias Carlström, Lucas Rannier Ribeiro Antonino Carvalho, Drielle Guimaraes, Ariela Boeder, Tomas A Schiffer
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Redox Biology
Subjects:
Ischemia-reperfusion
Reverse electron transfer
Dimethyl malonate
Kidney
Glomerular filtration rate
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723003853

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http://www.sciencedirect.com/science/article/pii/S2213231723003853

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