Renal tubule-specific Atgl deletion links kidney lipid metabolism to glucagon-like peptide 1 and insulin secretion independent of renal inflammation or lipotoxicity

Renal tubule-specific Atgl deletion links kidney lipid metabolism to glucagon-like peptide 1 and insulin secretion independent of renal inflammation or lipotoxicity

Objective: Lipotoxic injury from renal lipid accumulation in obesity and type 2 diabetes (T2D) is implicated in associated kidney damage. However, models examining effects of renal ectopic lipid accumulation independent of obesity or T2D are lacking. We generated renal tubule-specific adipose trigly...

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Bibliographic Details
Main Authors: Maria F. Fernandes, Juan J. Aristizabal-Henao, Phillip M. Marvyn, Iman M'Hiri, Meghan A. Wiens, Monica Hoang, Manuel Sebastian, Renato Nachbar, Philippe St-Pierre, Kalsha Diaguarachchige De Silva, Geoffrey A. Wood, Jamie W. Joseph, Christine A. Doucette, André Marette, Ken D. Stark, Robin E. Duncan
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Molecular Metabolism
Subjects:
Adipose triglyceride lipase (ATGL)
Renal tubule cells
Lysophosphatidic acid
Glucagon-like peptide 1
Glucose-stimulated insulin secretion
Diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824000188

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http://www.sciencedirect.com/science/article/pii/S2212877824000188

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