Retreatment with HBV siRNA Results in Additional Reduction in HBV Antigenemia and Immune Stimulation in the AAV-HBV Mouse Model

Retreatment with HBV siRNA Results in Additional Reduction in HBV Antigenemia and Immune Stimulation in the AAV-HBV Mouse Model

Background and Aims: Treatment with siRNAs that target HBV has demonstrated robust declines in HBV antigens. This effect is also observed in the AAV-HBV mouse model, which was used to investigate if two cycles of GalNAc-HBV-siRNA treatment could induce deeper declines in HBsAg levels or prevent rebo...

Full description

Bibliographic Details
Main Authors: Ellen Van Gulck, Nádia Conceição-Neto, Liese Aerts, Wim Pierson, Lore Verschueren, Mara Vleeschouwer, Vinod Krishna, Isabel Nájera, Frederik Pauwels
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Viruses
Subjects:
liver
T-cell exhaustion
sequencing
Trem2
hepatitis surface antigen
Online Access:https://www.mdpi.com/1999-4915/16/3/347

Internet

https://www.mdpi.com/1999-4915/16/3/347

Similar Items