Early cognitive comorbidities before disease onset: A common symptom towards prevention of related brain diseases?

Brain diseases are very heterogeneous; however they also display multiple common risk factors and comorbidities. With a paucity of disease-modifying therapies, prevention became a health priority. Towards prevention, one strategy is to focus on similar symptoms of brain diseases occurring before dis...

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Main Author: Laetitia Chauvière
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Heliyon
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844022035472
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author Laetitia Chauvière
author_facet Laetitia Chauvière
author_sort Laetitia Chauvière
collection DOAJ
description Brain diseases are very heterogeneous; however they also display multiple common risk factors and comorbidities. With a paucity of disease-modifying therapies, prevention became a health priority. Towards prevention, one strategy is to focus on similar symptoms of brain diseases occurring before disease onset. Cognitive deficits are a promising candidate as they occur across brain diseases before disease onset. Based on recent research, this review highlights the similarity of brain diseases and discusses how early cognitive deficits can be exploited to tackle disease prevention. After briefly introducing common risk factors, I review common comorbidities across brain diseases, with a focus on cognitive deficits before disease onset, reporting both experimental and clinical findings. Next, I describe network abnormalities associated with early cognitive deficits and discuss how these abnormalities can be targeted to prevent disease onset. A scenario on brain disease etiology with the idea that early cognitive deficits may constitute a common symptom of brain diseases is proposed.
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spelling doaj.art-8ca15859a8b74afd972ca573eb20bcf02023-01-05T08:39:37ZengElsevierHeliyon2405-84402022-12-01812e12259Early cognitive comorbidities before disease onset: A common symptom towards prevention of related brain diseases?Laetitia Chauvière0Corresponding author.; Radboudumc, Department of Cognitive Neuroscience, Trigon Building / Route 205, Kapittelweg 29, Nijmegen 6525, EN, the NetherlandsBrain diseases are very heterogeneous; however they also display multiple common risk factors and comorbidities. With a paucity of disease-modifying therapies, prevention became a health priority. Towards prevention, one strategy is to focus on similar symptoms of brain diseases occurring before disease onset. Cognitive deficits are a promising candidate as they occur across brain diseases before disease onset. Based on recent research, this review highlights the similarity of brain diseases and discusses how early cognitive deficits can be exploited to tackle disease prevention. After briefly introducing common risk factors, I review common comorbidities across brain diseases, with a focus on cognitive deficits before disease onset, reporting both experimental and clinical findings. Next, I describe network abnormalities associated with early cognitive deficits and discuss how these abnormalities can be targeted to prevent disease onset. A scenario on brain disease etiology with the idea that early cognitive deficits may constitute a common symptom of brain diseases is proposed.http://www.sciencedirect.com/science/article/pii/S2405844022035472Cognitive deficitsPreventionPredictionRelated brain diseasesBrain network abnormalitiesRisk factors
spellingShingle Laetitia Chauvière
Early cognitive comorbidities before disease onset: A common symptom towards prevention of related brain diseases?
Heliyon
Cognitive deficits
Prevention
Prediction
Related brain diseases
Brain network abnormalities
Risk factors
title Early cognitive comorbidities before disease onset: A common symptom towards prevention of related brain diseases?
title_full Early cognitive comorbidities before disease onset: A common symptom towards prevention of related brain diseases?
title_fullStr Early cognitive comorbidities before disease onset: A common symptom towards prevention of related brain diseases?
title_full_unstemmed Early cognitive comorbidities before disease onset: A common symptom towards prevention of related brain diseases?
title_short Early cognitive comorbidities before disease onset: A common symptom towards prevention of related brain diseases?
title_sort early cognitive comorbidities before disease onset a common symptom towards prevention of related brain diseases
topic Cognitive deficits
Prevention
Prediction
Related brain diseases
Brain network abnormalities
Risk factors
url http://www.sciencedirect.com/science/article/pii/S2405844022035472
work_keys_str_mv AT laetitiachauviere earlycognitivecomorbiditiesbeforediseaseonsetacommonsymptomtowardspreventionofrelatedbraindiseases