Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease.

Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease.

Parkinson's disease (PD) is the second most common neurodegenerative disorder of aging. The pathological hallmark of PD is neuronal inclusions termed Lewy bodies whose main component is alpha-synuclein protein. The finding of these Lewy bodies in the intestinal enteric nerves led to the hypothe...

Full description

Bibliographic Details
Main Authors: Christopher B Forsyth, Kathleen M Shannon, Jeffrey H Kordower, Robin M Voigt, Maliha Shaikh, Jean A Jaglin, Jacob D Estes, Hemraj B Dodiya, Ali Keshavarzian
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3228722?pdf=render

Internet

http://europepmc.org/articles/PMC3228722?pdf=render

Similar Items