Stage-specific dual function: EZH2 regulates human erythropoiesis by eliciting histone and non-histone methylation

Stage-specific dual function: EZH2 regulates human erythropoiesis by eliciting histone and non-histone methylation

Enhancer of zeste homolog 2 (EZH2) is the lysine methyltransferase of polycomb repressive complex 2 (PRC2) that catalyzes H3K27 tri-methylation. Aberrant expression and loss-of-function mutations of EZH2 have been demonstrated to be tightly associated with the pathogenesis of various myeloid malign...

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Main Authors: Mengjia Li, Donghao Liu, Fumin Xue, Hengchao Zhang, Qianqian Yang, Lei Sun, Xiaoli Qu, Xiuyun Wu, Huizhi Zhao, Jing Liu, Qiaozhen Kang, Ting Wang, Xiuli An, Lixiang Chen
Format: Article
Language:English
Published: Ferrata Storti Foundation 2023-04-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/11039

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https://haematologica.org/article/view/11039

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