Single-cell profiling of peripheral neuroblastic tumors identifies an aggressive transitional state that bridges an adrenergic-mesenchymal trajectory

Single-cell profiling of peripheral neuroblastic tumors identifies an aggressive transitional state that bridges an adrenergic-mesenchymal trajectory

Summary: Peripheral neuroblastic tumors (PNTs) represent a spectrum of neural-crest-derived tumors, including neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. Malignant cells in PNTs are theorized to interconvert between adrenergic/noradrenergic and mesenchymal/neural crest cell states. Here...

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Bibliographic Details
Main Authors: Xiaojun Yuan, Janith A. Seneviratne, Shibei Du, Ying Xu, Yijun Chen, Qianya Jin, Xuanxuan Jin, Anushree Balachandran, Shihao Huang, Yanli Xu, Yue Zhai, Liumei Lu, Mengjie Tang, Yushuang Dong, Belamy B. Cheung, Glenn M. Marshall, Weiyang Shi, Daniel R. Carter, Chao Zhang
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722012967

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http://www.sciencedirect.com/science/article/pii/S2211124722012967

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