The benefit of adding polygenic risk scores, lifestyle factors, and breast density to family history and genetic status for breast cancer risk and surveillance classification of unaffected women from germline CHEK2 c.1100delC families

The benefit of adding polygenic risk scores, lifestyle factors, and breast density to family history and genetic status for breast cancer risk and surveillance classification of unaffected women from germline CHEK2 c.1100delC families

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To determine the changes in surveillance category by adding a polygenic risk score based on 311 breast cancer (BC)-associated variants (PRS311), questionnaire-based risk factors and breast density on personalized BC risk in unaffected women from Dutch CHEK2 c.1100delC families.In total, 117 unaffect...

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Bibliographic Details
Main Authors: Maartje A.C. Schreurs, Teresa Ramón y Cajal, Muriel A. Adank, J. Margriet Collée, Antoinette Hollestelle, Jeroen van Rooij, Marjanka K. Schmidt, Maartje J. Hooning
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Breast
Subjects:
CHEK2 c.1100delC
Breast cancer
Risk prediction
Online Access:http://www.sciencedirect.com/science/article/pii/S0960977624000559

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http://www.sciencedirect.com/science/article/pii/S0960977624000559

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