BRCA Mutations in Prostate Cancer: Assessment, Implications and Treatment Considerations

BRCA Mutations in Prostate Cancer: Assessment, Implications and Treatment Considerations

Prostate cancer ranks fifth in cancer-related mortality in men worldwide. DNA damage is implicated in cancer and DNA damage response (DDR) pathways are in place against this to maintain genomic stability. Impaired DDR pathways play a role in prostate carcinogenesis and germline or somatic mutations...

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Bibliographic Details
Main Authors: Sidrah Shah, Rachelle Rachmat, Synthia Enyioma, Aruni Ghose, Antonios Revythis, Stergios Boussios
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
prostate cancer
DNA damage repair
<i>BRCA</i> mutations
PARP inhibitors
Online Access:https://www.mdpi.com/1422-0067/22/23/12628

Internet

https://www.mdpi.com/1422-0067/22/23/12628

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