The Specificity and Broad Multitarget Properties of Ligands for the Free Fatty Acid Receptors FFA3/GPR41 and FFA2/GPR43 and the Related Hydroxycarboxylic Acid Receptor HCA2/GPR109A

The Specificity and Broad Multitarget Properties of Ligands for the Free Fatty Acid Receptors FFA3/GPR41 and FFA2/GPR43 and the Related Hydroxycarboxylic Acid Receptor HCA2/GPR109A

The paradigm of ligand-receptor interactions postulated as “one compound—one target” has been evolving; a multi-target, pleiotropic approach is now considered to be realistic. Novel series of 1,4,5,6,7,8-hexahydro-5-oxoquinolines, pyranopyrimidines and S-alkyl derivatives of pyranopyrimidines have b...

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Bibliographic Details
Main Authors: Egils Bisenieks, Brigita Vigante, Ramona Petrovska, Baiba Turovska, Ruslan Muhamadejev, Vitalijs Soloduns, Astrida Velena, Karlis Pajuste, Luciano Saso, Janis Klovins, Gunars Duburs, Ilona Mandrika
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Pharmaceuticals
Subjects:
G-protein-coupled receptors
multi-target ligands
FFA3/GPR41
FFA2/GPR43
HCA2/GPR109A
electron-donating compounds
Online Access:https://www.mdpi.com/1424-8247/14/10/987

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https://www.mdpi.com/1424-8247/14/10/987

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