A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation

A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation

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Summary: Mutations in a number of chromatin modifiers are associated with human neurological disorders. KDM5C, a histone H3 lysine 4 di- and tri-methyl (H3K4me2/3)-specific demethylase, is frequently mutated in X-linked intellectual disability (XLID) patients. Here, we report that disruption of the...

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Bibliographic Details
Main Authors: Shigeki Iwase, Emily Brookes, Saurabh Agarwal, Aimee I. Badeaux, Hikaru Ito, Christina N. Vallianatos, Giulio Srubek Tomassy, Tomas Kasza, Grace Lin, Andrew Thompson, Lei Gu, Kenneth Y. Kwan, Chinfei Chen, Maureen A. Sartor, Brian Egan, Jun Xu, Yang Shi
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715015478

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http://www.sciencedirect.com/science/article/pii/S2211124715015478

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