The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization

The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization

The Parkinson's-disease-associated LRRK2 kinase phosphorylates multiple Rab GTPases including Rab8 and Rab10, which enhances their binding to RILPL1 and RILPL2. The nascent interaction between phospho-Rab10 and RILPL1 blocks ciliogenesis in vitro and in the intact brain, and interferes with the...

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Bibliographic Details
Main Authors: Antonio Jesús Lara Ordóñez, Rachel Fasiczka, Belén Fernández, Yahaira Naaldijk, Elena Fdez, Marian Blanca Ramírez, Sébastien Phan, Daniela Boassa, Sabine Hilfiker
Format: Article
Language:English
Published: The Company of Biologists 2022-08-01
Series:Biology Open
Subjects:
lrrk2
rab gtpase
rilpl1
vps35
ppm1h
centrosome
Online Access:http://bio.biologists.org/content/11/8/bio059468

Internet

http://bio.biologists.org/content/11/8/bio059468

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