Chimeric immune checkpoint protein vaccines inhibit the tumorigenesis and growth of rat cholangiocarcinoma

Chimeric immune checkpoint protein vaccines inhibit the tumorigenesis and growth of rat cholangiocarcinoma

Cholangiocarcinoma (CCA) is the second most common primary liver malignancy and carries a dismal prognosis due to difficulties in achieving an optimal resection, and poor response to current standard-of-care systemic therapies. We previously devised a CTLA4-PD-L1 DNA cancer vaccine (DNA vaccine) and...

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Bibliographic Details
Main Authors: Yi-Ru Pan, Chiao-En Wu, Wen-Kuan Huang, Ming-Huang Chen, Keng-Hsueh Lan, Chun-Nan Yeh
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
cholangiocarcinoma
immune checkpoint proteins
protein vaccine
immune modulation
therapeutic vaccine
preventive vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.982196/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.982196/full

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