Mouse Dspp frameshift model of human dentinogenesis imperfecta

Abstract Non-syndromic inherited defects of tooth dentin are caused by two classes of dominant negative/gain-of-function mutations in dentin sialophosphoprotein (DSPP): 5′ mutations affecting an N-terminal targeting sequence and 3′ mutations that shift translation into the − 1 reading frame. DSPP de...

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Bibliographic Details
Main Authors: Tian Liang, Yuanyuan Hu, Hong Zhang, Qian Xu, Charles E. Smith, Chuhua Zhang, Jung-Wook Kim, Shih-Kai Wang, Thomas L. Saunders, Yongbo Lu, Jan C.-C. Hu, James P. Simmer
Format: Article
Language:English
Published: Nature Portfolio 2021-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-00219-4