3D in vitro modelling of post-partum cardiovascular health reveals unique characteristics and signatures following hypertensive disorders in pregnancy

3D in vitro modelling of post-partum cardiovascular health reveals unique characteristics and signatures following hypertensive disorders in pregnancy

Abstract Background Hypertensive disorders of pregnancy (HDP) affect 2–8% of pregnancies and are associated postpartum with increased cardiovascular disease (CVD) risk, although mechanisms are poorly understood. Methods Human induced pluripotent stem cells (iPSC)-derived cardiomyocytes, cardiac fibr...

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Bibliographic Details
Main Authors: Clara Liu Chung Ming, Dillan Pienaar, Sahar Ghorbanpour, Hao Chen, Lynne Margaret Roberts, Louise Cole, Kristine C. McGrath, Matthew P. Padula, Amanda Henry, Carmine Gentile, Lana McClements
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Biology of Sex Differences
Subjects:
Pregnancy
Hypertensive disorders of pregnancy
Cardiovascular disease
Post-partum
Biomarkers
Proteomics
Online Access:https://doi.org/10.1186/s13293-024-00672-6

Internet

https://doi.org/10.1186/s13293-024-00672-6

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