Exploring Excitotoxicity and Regulation of a Constitutively Active TRP Ca2+ Channel in Drosophila

Unregulated Ca2+ influx affects intracellular Ca2+ homoeostasis, which may lead to neuronal death. In Drosophila, following the activation of rhodopsin the TRP Ca2+ channel is open to mediate the light-dependent depolarization. A constitutively active TRP channel triggers the degeneration of TrpP365...

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Bibliographic Details
Main Authors: Bih-Hwa Shieh, Lucinda Nuzum, Inga Kristaponyte
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Fly
Subjects:
Online Access:http://dx.doi.org/10.1080/19336934.2020.1851586