Brain insulin signaling suppresses lipolysis in the absence of peripheral insulin receptors and requires the MAPK pathway

Brain insulin signaling suppresses lipolysis in the absence of peripheral insulin receptors and requires the MAPK pathway

Objectives: Insulin's ability to counterbalance catecholamine-induced lipolysis defines insulin action in adipose tissue. Insulin suppresses lipolysis directly at the level of the adipocyte and indirectly through signaling in the brain. Here, we further characterized the role of brain insulin s...

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Bibliographic Details
Main Authors: Matthäus Metz, James O'Hare, Bob Cheng, Michelle Puchowicz, Christoph Buettner, Thomas Scherer
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Molecular Metabolism
Subjects:
Brain insulin signaling
Lipolysis
Hypothalamus
MAPK
Mitogen-activated protein kinase
ERK
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877823000571

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http://www.sciencedirect.com/science/article/pii/S2212877823000571

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