Hepatotoxicity assessment investigations on PFASs targeting L-FABP using binding affinity data and machine learning-based QSAR model

Hepatotoxicity assessment investigations on PFASs targeting L-FABP using binding affinity data and machine learning-based QSAR model

Per- and polyfluoroalkyl substances (PFASs) are persistent organic pollutants that have been detected in various environmental media and human serum, but their safety assessment remains challenging. PFASs may accumulate in liver tissues and cause hepatotoxicity by binding to liver fatty acid binding...

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Bibliographic Details
Main Authors: Jiayi Zhao, Xiaoyue Shi, Zhiqin Wang, Sijie Xiong, Yongfeng Lin, Xiaoran Wei, Yanwei Li, Xiaowen Tang
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
PFASs
L-FABP
Binding affinity
Machine learning
Bayesian Kernel Machine Regression
Online Access:http://www.sciencedirect.com/science/article/pii/S014765132300814X

Internet

http://www.sciencedirect.com/science/article/pii/S014765132300814X

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