Construction and drug screening of Co-culture system using extrahepatic cholangiocarcinoma organoids and tumor-associated macrophages

Construction and drug screening of Co-culture system using extrahepatic cholangiocarcinoma organoids and tumor-associated macrophages

Patient-derived organoids (PDOs) have been proposed as a novel in vitro tumor model that can be applied to tumor research and drug screening. However, current tumor organoid models lack components of the tumor microenvironment, particularly tumor-associated macrophages(TAMs).We collected peripheral...

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Bibliographic Details
Main Authors: Yinghao Guo, Qi Li, Qinghuang Ye, Yun Jin, Yuanquan Yu, Xiaoxiao Zhang, Longfu Xi, Yihang Wang, Di Wu, Yanzhi Pan, Shumei Wei, Qingyong Li, Huiquan Wang, Jiangtao Li
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Heliyon
Subjects:
Extrahepatic cholangiocarcinoma
Organoids
Tumor-associated macrophages
Genetic profiles
Therapy resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024124085

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http://www.sciencedirect.com/science/article/pii/S2405844024124085

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