CCL5 promotes LFA-1 expression in Th17 cells and induces LCK and ZAP70 activation in a mouse model of Parkinson’s disease

CCL5 promotes LFA-1 expression in Th17 cells and induces LCK and ZAP70 activation in a mouse model of Parkinson’s disease

BackgroundParkinson’s disease (PD), which is associated to autoimmune disorders, is characterized by the pathological deposition of alpha-synuclein (α-Syn) and loss of dopaminergic (DA) neurons. Th17 cells are thought to be responsible for the direct loss of DA neurons. C-C chemokine ligand 5 (CCL5)...

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Bibliographic Details
Main Authors: Jingwei Zhao, Ke An, Zhijuan Mao, Yi Qu, Danlei Wang, Jiangting Li, Zhe Min, Zheng Xue
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
Parkinson’s disease
Th17
CCL5
LFA-1
plck
pZAP70
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1250685/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2023.1250685/full

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