Platelet Protease Activated Receptor 1 Is Involved in the Hemostatic Effect of 20(S)-Protopanaxadiol by Regulating Calcium Signaling

Platelet Protease Activated Receptor 1 Is Involved in the Hemostatic Effect of 20(S)-Protopanaxadiol by Regulating Calcium Signaling

Panax notoginseng (Burk.) F.H. Chen has long been used to stop bleeding for hundreds of years in China. At present, only dencichine, notoginsenoside Ft1, and 20(S)-protopanaxadiol (PPD) showed hemostatic effect. However, the molecular mechanism of PPD on the platelet aggragetion needs to be further...

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Bibliographic Details
Main Authors: He Zhang, Daian Pan, Xingquan Wu, Wenjie Su, Xiaolei Tang, Daqing Zhao, Liwei Sun, Bailin Song, Xueyuan Bai, Xiangyan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
20(S)-protopanaxadiol
hemostatic effect
platelet
protease-activated receptor 1
vorapaxar
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.549150/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.549150/full

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